What is the first-line medication class used to manage hypertension?

Thiazide diuretics are considered the first-line medication class for managing hypertension due to their effectiveness in lowering blood pressure and their favorable long-term outcomes in numerous clinical studies. Thiazides work by promoting diuresis, which reduces blood volume and, consequently, blood pressure. They also have additional cardiovascular benefits, such as reducing the incidence of heart attacks and strokes.

Their use is often recommended as a foundational treatment in various clinical guidelines for patients with essential hypertension, especially in those who have no specific contraindications. The mechanism of action helps reduce peripheral vascular resistance over time, thereby contributing to the overall management of hypertension.

Other classes, while effective in certain populations or specific cases, are not prioritized as first-line options across the general population with hypertension.