What is a significant complication associated with long-term steroid use in asthma patients?

Long-term steroid use, particularly in asthma patients, can lead to adrenal suppression and various systemic side effects that significantly impact overall health. Corticosteroids, when used chronically, can diminish the adrenal gland's ability to produce natural steroids, leading to a condition known as adrenal insufficiency. This is critical because the body relies on these natural hormones to manage stress and maintain metabolic processes.

In addition to adrenal suppression, long-term use of steroids can result in systemic side effects, including weight gain, increased susceptibility to infections, osteoporosis, and hypertension. The range of complications underscores the need for careful monitoring and management to balance the treatment of asthma while minimizing risks associated with steroid therapy.